Need Help? Hz and Hb have typical absorption spectra, with characteristic absorption peaks, that change their shape according to their concentrations.
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Skip to Main Content. In this work, it was studied the optical absorbance of Hz and whole blood WB samples, with different concentrations of both Hz and Hb.
Hemozoin and hemoglobin characterization by optical absorption towards a miniaturized spectrophotometric malaria diagnostic system Abstract: Malaria is a parasitic disease with high prevalence in regions with inefficient healthcare conditions.
Persistent Link: The miniaturization capacity was tested using 1 mm optical path quartz cuvettes and 3 mm optical path polydimethylsiloxane wells, where WB samples with different Hz concentration were introduced. Overall, this work presented the spectrophotometric basis and proof of concept towards the development of a lab-on-a-chip device for malaria detection in WB.
The results showed high linearity of the absorbance curve, as a function of the concentration, with R 2 between 0. A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.
Additionally, with the aim of miniaturization, different solution volumes and different optical paths were considered. Use of this web site signifies your agreement to the terms and conditions.
Currently, the most used diagnostic methods in endemic regions are microscopy and rapid diagnostic tests by immunochromatographic assays. Hz is a subproduct of the malaria parasite, produced by degradation of Hb, inside the red blood cells and, as the malaria parasite is proliferating, the Hz concentration increases and the Hb decreases. Sign In. Institutional Sign In.